Research has shown that cannabidiol (CBD) has the potential to effectively help a large number of people. CBD oil interacts with the endocannabinoid system in a way that produces very few side effects. Although science indicates that it is safe, it has some risks that, if not well understood, could be dangerous.
Inhibition of the cytochrome P450 enzyme system
Found in the liver, the cytochrome P450 enzyme system is responsible for the metabolism of potentially toxic compounds, including more than 60% of all the drugs you take. One of the contraindications to CBD is related to its interaction with this enzyme. Cannabidiol may inhibit the ability of the cytochrome P450 system to metabolize certain drugs, resulting in an overall increase in treatment times.
When the CYP450 system is affected in this way, it leads to higher levels of certain drugs in your body at a given time. This can lead to unwanted side effects and sometimes an overdose.
If you are taking a drug affected by cannabidiol, you should consult your doctor to make sure that CBD oil does not pose a potential health hazard to you. Based on this, you may want to consider changing the dosage of your medications to ensure the safe use of both products.
Drugs that interact with cannabidiol
Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include steroids, calcium channel blockers, antihistamines, anti-HIV antivirals, immune modulators, antibiotics, anesthetics, and beta-blockers.
This list does not include all drugs that are contraindications to CBD. For these reasons, you should consult a health care professional before including CBD oil in your daily diet.
Combination of alcohol and CBD oil
Alcohol and cannabis are both widely used substances in our society and the effects of the combination of the two are well known. What is less understood by the general public are the contraindications to CBD in relation to alcohol consumption. The latter depends on a few different metabolic pathways in the human body, the main enzymes involved being Alcohol Dehydrogenase (ADH), Aldehyde Dehydrogenase (ALDH) and CYP2E1. CBD and alcohol can amplify each other’s effects, and taking both together in high doses can cause drowsiness and sedation. According to a recent study, when a person drank alcohol with CBD, there were “significant alterations in motor and psychomotor performance, overestimates of time production and subjective responses indicating accurate self-perception of their intoxication and deficits.